Doubt you can have too much current......
Like mentioned previously lots of us run huge Korilias along with the 10-20X turnover..... I had over 10K gph just in Korilias in my big tank before the pieces of crap all failed.......
I guess I don't worry that much about pluming loss cause there really isn't going to be that much if you plum it properly, most decent external pumps don't loose much with typical head height, especially in setups like mine where the bottom tanks have a whopping 18" of head.