It is a bit harder to produce foam in fresh, compared to salt water.
I believe most protein skimmer pumps chosen are simply too wimpy to produce the agitation needed to break the tension of the air water interface to separate DOC, solids, and other components.
Fractionation happens in nature all the time, and foam you see below a waterfall, is fractionated. You will also find it in creeks in spring where fast water breaks tension as it rushes over rocks.
Beside removing DOC, and other components, I did bacterial, algae, and other microscopic animal counts of normal tank water, compared to the foam/ fractionator waste water, and found these populations coincided with the dry weight comparison.