Just like any type of filtration, sand reactors obviously stop during an outage, but the media is submerged, so if the outage is not too long, some will bacteria survive. If the outage is long, you start the cycle over.
A good sand creator will need a check valve to prevent back siphonage during an outage.
At first I built mine pressurized, but ended up open top, to make it easier to maintain.
Mine was large (4ft tall) and weighed quite a bit filled with pounds of media and gallons of water, so getting it started agin under pressure was a wrestling match. Open topped was much easier, and I could add media without shutting it down.