The frequency of media change will depend upon the individual conditions within your tank. Specifically, the number and size of fish, frequency of feeding, etc. However, for the sake of discussion, I run two Rena XP3s on a well stocked 150 gallon Dat tank and disassemble and clean the filters approx. every month. Sometimes I let them go for 6 weeks. I abandoned carbon about two years ago and have never looked back. I use coarse/medium/fine mechanical pad filtration followed by biological filtration media, consisting of Efhisubstrat Pro. 1/3 of the internal filter volume is devoted to mechanical media and 2/3 to biological media.