It's helpful to tell us how uneven the floor is, but I'm going to assume it's 1 cm or less. That is to say, one side of the tank (front to back or side to side) is no more than 1 cm difference in height from the other side. I've leveled tanks with that much difference but not more so while others may have experience using shims to correct for several cm's, I don't.
I think you can use metal or wooden shims to level a stand on an uneven floor as I did. Shims are easy to place, relatively strong (especially metal ones), and at least for wooden ones, not expensive. Wood is a very strong material under compression, so wood is what a lot of people use.
If you use a sheet of acrylic, it's possible it would work out just fine, but I'm not able to say that it won't fracture under that stress since I've never used it. Keep in mind that regardless of what you use, you will want the entire side shimmed or raised up evenly across that side, not simply 1 corner.
So the sheet (if you use it) must either be that long or you will need more that 1 piece.
I recommend a couple photos. People will want to see the tank and help you get it set up perfectly.