In SW they are used to take advantage of the de-nitrifying (removes nitrate) capabilities of the bacteria that lives in the areas of the sand bed that have very little-no oxygen present... Sand is used to create a deep sand bed (as the name suggests), gravel is too corase and allows a lot more oxygen into the lower layers of the substrate. This concept might be able to work with a FW, but honestly, I don't have a good reason to find out, 'cause...
Really in FW, the best way to lower nitrate (and any thing else you don't want in the water) is just water changes... It's so simple I don't think any other way is worth my time to look into... If work is a problem, set up an auto water changer, or maybe get a python (if your still hualing buckets around).