I tried it and did not have a good experience. Luckily, it was only a ten gallon sump, but it still made quite a mess.
When it came time to set up my 220, HOB overflows weren’t even considered. I drilled five holes in that beast and it is now capable of flowing 3600 gph. I only run it at about 1600 though. But I have no worries about losing the siphon in the overflow.
I highly recommend you go ahead and drill the tank if it’s not tempered glass. It’s not as bad as you think.