With the right bits and technique, you can drill a hole in glass using a dremel, rotozip, or drill press. That being said, if you only need a couple holes, don't waste the time or effort trying to DIY.
Most local glass shops will drill holes for ~$15/hole. I highly advise having your tank drilled. Also, make sure you leave enough room for durso standpipes, as they will go a long way towards quieting things down. Hang on overflows are absolute disasters waiting to happen.