Actually...
When scientists are doing an experiment on breeding... The first batch of offspring are F1... the second are F2... etc...
It doesn't matter if the originals are wild caught, hybrids or a pure aquarium strain.
Then we borrowed their labeling system to describe how far our fish are from wild caught and create the infamous "F0" label for our wilds. This numbering system was not created to deal with crossing generations, such as breeding F1 x F4. In a science experiment when crossing two different generations (which would be rare/odd) there would be a full description of what they bred and why...
At least that's the story I've always heard... there are articles out there that explain it this way as well.
Edit/PS - Bruce is probably right also, as hybrid creators could also borrow this same labeling system to track their hybrids. I didn't mean to sound like I was trying to "correct" anyone.