Ultimas/DEs/etc will be perfect for mechanical filtration, and I mean perfect. But then you need to look into bio filtration. On a tank that size, you will probably want a sump just to make things more flexible. Then you can attach input/output from the ultima/de/whatever in the sump and get nice polished water without worrying about in-tank obtrusions/drilling all over the tank. In the sump, I would personally do submerged biomedia, but that's just because I hate noise and, no matter what anyone will tell you, wet/drys sound a little waterfall-y/trickle-y. For a tank that size, 200-300 gallons of sump should give you room for media and equipment (heaters/heat exchangers/pumps/mechanical/bio/sponges/whatevs).