Discus, despite having been domesticated for 50+ years, remain weak and impossible to breed in hard water.
Difficult to breed, yes, but certainly not weak when kept in hard water, not at all. I have seen many locals keeping many discus thriving long term in our local water, which is pH 8.0, and hard. No HITH, no Spiro/Hex, all good for many years. Typically the weaker discus are the Asian designer fish, which is due to genetics, not water conditions.
So which fish did not like your water and what's you tap water like? In theory alkaline water carries a higher bacterial count than acidic, did your fish just seem unable to keep their immune system up and die to things like hex?
A couple of examples ....... some species are more sensitive than others, such as some of the Satanoperca genus. These fish tend to come down with issues such as HITH, even in low stress environments, with low organics, nitrates typically at 5 ppm. As the fish mature, over a few years, some of them seem to develop a lower immune response, and become more susceptible to pathogens such as Spironucleus, which then triggers HITH outbreaks. NOT diet related, NOT nitrate/organics related - but these fish in their native environment would live in a more acidic water, where most of the bacteria in harder more alkaline water would not exist. This same native water also contains tannins, turpines, etc found in native leaves/bark etc that are known to have anti-bacterial properties. Remove the fish from that protective environment and introduce them to some of our local nasties and some fish don't hold up well over the long haul.
Even beyond pH/GH/KH/TDS etc, our local water in the winter is ice cold, 50F on a warm day coming out of the tap, and the gas created in our pipes in the winter months plays havoc with the slime coat of some species of SA fish, such as chocolate cichlids. (H. temporalis) So I no longer keep them either, as I don't have time to store water in vats etc.