Another way of interpreting his question is whether housing other species with Frontosa will inhibit them from breeding. And, in my experience, the answer can be yes. Frontosa need to be the kings of the tank (or better alone) or they won't spawn successfully. More aggressive Haps or other species can bully them.
As for hybridization between Cyphotilapia and another genus? Nope. Although, as others have noted, variants and species within Cyphotilapia will cross readily (not desirable).