Yes, but if you have enough bio in your filters and rocks, driftwood, flower pots, etc it wouldn't be anything that won't correct itself in a couple of days. As a precaution I usually change half the substrate then wait 2 weeks before changing the other side. When I upgrade tanks and don't want to use the existing substrate I'll set up with the new substrate and fill a couple of media bags with existing substrate and place them in the new tank for a couple of weeks.