I dont have any idea what you are asking. I think you might be confused a little yourself, or you are confusing me. so I will just ramble on a little with questions.
1. If you put in the 2.5 inch hole and bulk head, are you going to run a stand pipe?
If you dont run the stand pipe, the water pressure at the bottom of the tank will be the highest it can be with gravity, and the water weight on top. If a 2.5 inch hole can flow 4800GPH low pressure, I think you will be flowing a lot more then that without a stand pipe.
2. Now if this is for a closed loop set up, how big is the tank.
3. If you are trying to see if you can use thin walled PVC pipe? I absolutly would not on any aquarium.
4. Are you asking if it is even possible for a 2.5 inch hole to flow that much water?