Yes. The thing to be concerned with though is the waste getting trapped in the sand and creating harmful pockets of ammonia. Plecos create a lot of waste and cleanup can be a chore. I have personally taken sand out of two of my tanks that house plecos for these reasons. I just gave a friend a 4" L-205 to put in his planted tank with black sand and after two days he was whining about the poo on top of the sand.