Some people add metro to food, but it's not wise to do so IMO. There is a high risk of overdose this way, and overdose can damage internal organs. I use 100% metro directly to water. I do a 50 to 75% water change, use 1/4 teaspoon of metro per 40 gals. stirred up into a glass of hot water,and pour directly into the tank. This is repeated every day for one week. Metro tends to break down after 24 hours, and under lighting, so I turn the lights out and treat every day.