I do two 40% water changes every week and use Seachem's Prime as a conditioner. I test the waters parameters once a week after the second water change and so far everything's been pristine.
Yes the 350's do have 4 cartridge slots but i think they are necessary only because my 55 houses a Sanchezi piranha and they tend to be messy eaters.
How about the bio wheels? Ive never changed those...still adequate?