I can see potential clogging and ponding on your top coarse filter pad and/or wool resulting in overflow, a potential bottleneck with the 3 bulkheads between the sump tanks and lack of oxygen with your tall bio-tower. of course this is just a diagram so you may have accountd for these things.
Some suggestions;
Its poor use of bio cubes to use them sumberged since their open structure is designed for air flow.
If your bio-tower doesnt have air holes, run some airstones in the base to provide counter current aeration. Air rising and water falling means more gaseous contact time than if they are both falling.
Why dont you return the UV back into your bio filter to optmize pump usage? This will allow you to keep the sump running seperately if you ever ned to medicate the tank seperate.
I use bio-load rather than a tank size estimates so I am not going to suggest max tank size possible.