I did the same thing once in a smaller tank I use to grow out african cichlids. Just turn of the filters if you have canisters or hob so they do not suck up sand. I just added small amounts with a container I could put under water and poor the sand out almost on the bottom of the tank. It didn't seem to bother the fish at all.
Best to remove the fish first. How would you feel if dust enters your lungs?
That would be how the fish feels if you just pour PFS into your tank without removing the fish.