I personally think it would depend on number of skunks, decor and size of tank. I have two larger tyre track eels with my botia and they are fine. Although my skunk are nothing near as nippy as my eor were. Removed the eor but nothing to do with the eels.
Personally think you should be fine with the right decor and size, especially if there is other fish to take the attention of the skunks?