Depends on the plant. I take it you mean rooted ones? Do you use Flourish or misc fertilizer? Fertilizer tabs that you stick under the substrate?
I tend to use the latter, and Flourish, for my planted tanks. Since I use the tabs under the gravel, it would not be a good idea to go poking the Python in the gravel. So...I plant a lot, fertilize well, and don't use the Python in the substrate at all.