I have a 200lb pool sand filter on my 220g (overkill I know but I got rid of the swimming pool and had the filter just lying around). It works perfectly. I backwash it once a week doing a 50% w/c to keep it clean. It takes less than a minute, maybe about a 40 second backwash followed by a 10-15 second rinse. I piped the waste water straight to the sump pump catch basin so there's no hoses to run.
The pressure gauge on the filter always reads 15 psi, the filter never clogs and raises the pressure like it did when it was on the pool, so I just clean it anyway during my weekly water change. Backwashing is the quickest way to drain the tank, about 30 times faster than using a python.
That seems to be the only maintenance it needs to keep the detritus from builing up inside. The water is almost always crystal clear, although i'm sure a DE filter might work even better. If the room is dimly lit at night and you look through the side of the tank to the far end you can see a little hint of cloudiness, but not much. It is always crystal clear when viewing from the front.
The only complaint I have is the electricity. I'm using the original pool pump and it draws about 6 or 7 amps, but I'm sure if I looked i could find a more efficient pump. This one pushes about 1200 gallons per hour when its filtering, and I only have 1" pipe on the return. I'm thinking I should have gone bigger because I know it moves a lot more than 1200gph when I backwash and I used 1.5" pipe on the drain line.