I am in the process of building one around 500 gallons. I had 2x10 LVL laminate floor joists added along with the joists that were already there and had a structural engineer come out to ok it. If i were you i would hire a structural engineer to come out to take a look.
id go with a 150g max upstairs, i know a guy who had tanks running the length of his bedroom wall when he lived at home, after he left, his parents had a structural engineer in and there was a crack down the side of the extension.