I think plecos are more agressive then people say I have a common Bristle nose and it was destroying a larger senegal and oscar of mine so I had to move him, if he's the only pleco in the tank he will be fine I think this slightly more territorial pleco would be better with those tank mates because if anything where to happen it would be able to defend itself, But there are also stories of plecs sucking the slimcoat off bichir's bodies.