I would recommend drilling the holes in the top with at least the width of the hole worth of material on all sides of the hole... In English: If you drill a 1" hole you should have at least 1" of acrylic around all sides of the 1" hole. This will help reduce the chance of cracking. Likewise a 1" hole should be no closer than 1" from the side of the tank.
Smoothing the hole with sand paper will also help reduce the chance of the acrylic cracking. Round over the top and bottom of the hole slightly with the sand paper... so there is a slight radius / flare on the edges of the hole instead of a really hard 90 degree angle.
The area on the top of your tank between the existing access holes and the overflow hole is already a weaker area than the rest of the top. Avoid drilling any additional holes close to this area. The area between the access hole and the back of the tank should be fine for new holes as long as you stay a good few inches away from the overflow hole in the middle back of the tank.
Smoothing the hole with sand paper will also help reduce the chance of the acrylic cracking. Round over the top and bottom of the hole slightly with the sand paper... so there is a slight radius / flare on the edges of the hole instead of a really hard 90 degree angle.
The area on the top of your tank between the existing access holes and the overflow hole is already a weaker area than the rest of the top. Avoid drilling any additional holes close to this area. The area between the access hole and the back of the tank should be fine for new holes as long as you stay a good few inches away from the overflow hole in the middle back of the tank.
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