Depending on the species yes, but not a lot if any. What species do you have? In some species, the bristles are found on both male and females, but on females the bristles are usually just around the "lip" or head edge of the pleco and will generally not have as many as a male does. Males have the bristles all over the top of the head too, which if females have, is far smaller and to a much lesser extent. Some adult females can look like sub-adult males.
There are also little things like with Ancistrus Claro it is said that mature females have a darker base coloration, and the vermiform lines are found predominantly on males. Sometimes people say the shape and total size may also differ slightly between genders. To be honest though the sexing by head tentacles is your best bet.