I do 50% daily water changes on both my 150-gallon & 22-gallon sometimes even twice daily on the 150-gallon (if there is lots of poop on the bare-bottom-tank)
I just use a garden hose on the 150 and dose with Prime for the entire tank volume.
On the 22-gallon tank I treat the small amounts of water with PRIME FIRST, then add it by hand with a few trips and a rubbermaid box.
I do it this way on the 22-gallon because I can

I am sure its better to treat the tap water itself before adding it to the tank, plus you can use less Prime.
But with the large tanks/garden hoses this is not possible.
I usually treat the whole 150 gallon tank with 4-caps of Prime during a 50% change, adding the 4th cap at the end of the change just for some extra protection, so I end up treating 200-gallons of water.
Been doing this for MONTHS now with no problems, except that I am using lots of Prime
I ordered my first 1.1-gallon container of Prime the other day from Big Als I used to buy the 250ml! Then I thought I will buy the 500ml (which seems a bit harder to find) but I plan on using the 1.1-gallon from now on.