What size is the flowerhorn, & the orange Pike? We kept our trio of Cobras in a tank with a breeding pair of flowerhorns for a few months. The pikes are quicker, usually can elude the slower flowerhorns. They would raid the swarm of fry, eventually clean them out - the flowerhorns hated them... The trick was having enough cover - rock shelves, driftwood, etc., for the pikes to hide under. I really wouldn't recomend keeping them together, we lost one Cobra when we were out of town cuz he really messed up an eye, probably escaping the angry flowerhorns. Good luck whatever you do....