Ive had one running on my 75 for 2 yrs, and my fish are colorful robust and healthy. I have a UV sterilizer rated for 250 gallons on it also which i was told will kill internal parasites if the water passes threw it slower, and so far has proven true as far as i can see. Ive also sold and traded fish and I know they are still alive and healthy in tanks without them. Its controversial, but from my personal experiences i dont see why you would not want a tank with crystal clear water and free of disease(Not one of my fish has been sick since Ive had it litterally) just my 2 cents....