There are diseases that are species specific, so having only the Acara's infected is not a surprise, especially if other Acaras were infected before.
It may be that in between time, the phage became inert but was re-awakened when new Acaras were added..
I cannot tell what the disease is.
If its Lymphocystis, no meds will help, because Lymph is viral.
Only a much more stringent water quality regime will help
If its bacterial, you may need a specific antibiotic, so general cure type meds, my not be enough.
But beyond that, I find a 40% water change a very lax water change regimes, in fact I find a 40% water change only once per week quite lax.
Since this disease is not new for you, you may want to consider revamping your entire regime.
I do 30% to 40% water changes on my 300 gal system every other day.