i've got a 180, had a large silver aro, a large tiger shovelnose, a large green terror, a large malawi trout, and a good sized pleco. i run 2 aquaclear 500 power filters with chemi-pure, two small powerheads in the middle, 2 aquaclear 900 powerheads (one on each end). figured i turn the complete tank water over about every 3 to 4 minutes. i found once every 4 to six weeks worked for me.. i always kinda go for overkill on filtration...now have just the aro and pleco so the bioload is not as bad....