Yes, weight and height concerns are both very valid...but another one which seems to be largely underestimated by many rack-designers is space between the levels for access to the lower tanks.
IMHO, if you haven't got a full 12 inches of space to reach in and get down into the lower tank, you are going to be cursing your design forever! Inserting tools, nets, filters, plants, rocks, wood, etc. will be a horrific PITA. Even with a full foot of space, working in the lower tanks is miserable; it's just a fact of life with racks. Don't make it worse than it needs to be.
I made the too-tight mistake with the very first rack I built; it lasted a couple of years before I broke down and broke it down, to re-build with more space between levels.