Here's my situation. I have a 150 that has been set up for about 5-6 years with no problems. I had a 12" Butti, 5 clown loaches and 1 mbuna. A few weeks ago I bought a pleco. I was lazy and neglected my tank for a couple of weeks after buying the pleco, forgetting how much waste they produce. I was out of town for about 5 days and the day I was coming home my roomate called me and said that my loaches were all dead and the butti didn't look good. His eyes were cloudy and he was covered in white stuff. He called his friend who works at a fish store who told him to do a big water change and treat the tank with melafix. By the time I got home he was halfway through the water change. I was amazed by the amount of crap that was in the gravel, mostly pleco poop. So the water quality was probably pretty bad. A few hours later the butti was swimming around a little and the white stuff was falling off of him. Was this his slime coat? I also noticed that the white part of the rear of the fish was red as if infected. He was also breathing faster, my roomate said he was breathing very slowly and not moving before. His eyes were still VERY cloudy. The next morning he was swimming upside down and seemed disoriented. After a couple of hours he was dead. The butti was probably 8-10 years old. The mbuna was completely unaffected and the loaches were dead before my roomate noticed anything (who knows how long that was, he might not have looked at the tank for a couple of days.) Does anyone have any idea what this was? Should I treat the tank with anything before I add new fish? Thanks in advance for any input.