Don't do large water changes when a ray is stressed, it only compounds the situation. I would do 10% twice a day or 20% once a day.
If your other rays are fine it's likely not parameters, though it could be. Check if there is ammonia or nitrite in your water.
First thing, divide the fish so it is by itself. Some salt may help, but don't do too much and definitely don't start adding medication without identifying what's up. Post some more pictures for us to examine, it looks like maybe a fungal or bacterial infection. Right now stress is your worst enemy, so keep lights off, make sure you aren't spooking him often, and try feeding live worms or ghost shrimp.