Yea like the others have said it really depends on when you want the parents to spawn again. My con pair has spawned 6 times and 5 of the times I removed the fry after 2 weeks of them being free swimmers to use as feeders for my tiger barbs, and once I let the fry in to see how long they would last. In that case, the parents didn't spawn again until their fry were about an inch long or so.