wow 450 gallon makes it hard to treat for sure. If the sore is getting worse I would treat it for bacterial infection. I think your best bet would be medicated food but unfortunately you would have to treat everyone
If you can get him out we can consider topicals and dips as well vs treating a qt tank
could always try salt first if safe for your tank.
I did salt but backed off lately. I will try doing it again slightly higher, I did one cup per hundred gallons before
I see no "fuzz", but the patch has doubled in three months so I am concerned