XechOx ............. I never said that ethoxyquin is harmless. I have also never said that Vitamin A is harmless. Both substances can cause all sorts of health issues, in dogs, cats, rats, mice, humans, and even fish - when excessive quantities are consumed.
Perhaps I should have explained in more detail as to how the whole ethoxyquin fiasco started with dogs, back in I believe the late 1980's. At or around that time there were a few manufacturers of dog food that were making "new" premium type diets, high in protein, and high in fat - a lot higher than most previous dog food formulas on the market. Some people using these foods began seeing health issues in their dogs, and it was believed at the time that these conditions (and there were LOTS of various health issues reported, not just liver & kidney problems) were from some type of toxin. It was also at this time that some people within the dog industry began to speculate that these dog food manufacturers with their "new" formulas were adding FAR greater amounts of preservative to their food than in past decades, due to the higher protein and higher fat inclusion rates. (note to kmuda - this is why inclusion rates of a preservative have nothing to do with fish meal)
Just to be clear, I have never once stated that this did not happen, I honestly have no idea but it most certainly is in fact possible. Others speculated that it was possibly from local environmental toxins etc-etc, and was not diet related at all. Others felt it was from excessive use of terrestrial based grains, which again is quite plausible. Unfortunately I don't believe that anyone back then took samples of the food & tested for ethox levels (or anything else for that matter) so it all ended up as pure speculation. That, or by the time anyone did get around to testing the food those manufacturers had already cleaned up their act. Bottom line is no one knows exactly what caused all of these various health issues in all of these various dogs, but ethox was blamed by many.
Some of this is explained in more detail in the following report.
http://jn.nutrition.org/content/121/11_Suppl/S163.full.pdf
Interestingly enough, in some of the various studies that have been performed using this preservative, it has been shown to suppress the carcinogenic potential of a number of compounds.
That's right, it actually helps reduce certain types of cancer. I bet that no one saw that coming.
The incidences of mammary tumors, carcinomas and fibroaden-omas in DMBA-treated animals were reduced by diet containing BHA or ethoxyquin.
http://carcin.oxfordjournals.org/content/7/7/1155.abstract
From the Journal of Cancer Research .........
http://cancerres.aacrjournals.org/content/44/3/1072.full.pdf
Antioxidants are widely used in pharmaceutical products, food,
and cosmetics in order to prevent or retard fat autoxidation by
means of their radical scavenger properties (5, 45-47). The
synthetic antioxidants have been shown to protect against tumor
induction in a variety of rodent tissues by a variety of chemical
carcinogens, including benzo(a)pyrene, 7,12-dimethylbenz(a)-
anthracene, diethylnitrosamine, aflatoxin B,, and methylazoxymethanol
acetate (3, 13, 17, 22, 34, 41, 45, 46). Although the
mechanism by which antioxidants BHA, 3,5-ferf-butyl 4-hydroxytoluene,
and ethoxyquin inhibit chemical carcinogenesis is not
understood, recent investigations have implied that these agents
exert inhibitory effects either by altering carcinogen metabolism
or by reducing free radical reactions, thereby inhibiting lipid
peroxidation (
Biochemical labs describe ethoxyquin as; A synthetic antioxidant which inhibits chemically induced carcinogenesis. It exerts its chemopreventive action by inducing glutathione synthetase, one of the enzymes in the synthesis of glutathione, and the phase II drug metabolizing enzyme glutathione s-transferase(GST).
So there's more than just one side to this debate, and there are just as many studies (or more) out there that prove its value as a safe preservative, even acting to inhibit certain types of cancer in animals, as there are studies showing that the levels typically found in pet food are in any way unsafe.
Also note that I could have posted those links in my initial comment, I didn't bother because quite frankly they have about as much merit in this discussion as most of the other studies linked to & discussed thus far. (dogs, monkeys, mice, humans)
BTW - I am not posting any of this info to convince anyone of anything. Feel free to remain a skeptic, feed pellets, don't feed pellets, whatever, feed your fish Russian caviar for all I care, no skin off my nose.
My only reason for posting what I have is to demonstrate that there are always 2 sides to every story. I have been involved with this subject & this preservative & this industry for many years so my take on it is going to be different than most folks who thus far have only recently been subjected to one side of the debate.
Kmuda ......... I'm not exactly sure what fish protein digest is, but I suspect that it is a dry form of fish hydrolysate.
http://en.wikipedia.org/wiki/Fish_hydrolysate
When it comes to amino acid content, digestibility, palatability, as a raw ingredient in fish food fish meal is I think pretty much impossible to beat. A good read on this ingredient by a couple of non-biased experts in this field, R.D. Miles, Professor, Department of Animal Sciences, and F.A. Chapman, Associate Professor, Department of Fisheries and Aquatic Sciences; Florida Cooperative Extension Service, University of Florida.
http://edis.ifas.ufl.edu/pdffiles/FA/FA12200.pdf
On this we are in 110% agreement.
Yet those ingredients mentioned are all used in various formulas by a company that you support & endorse on your website.
