I have Eheim 2217'sa and also Eheim 2028's on set-ups as well as my 2 FX5's.
The FX5's have 325 sq in foam area (which can also be used for bio-media instead),
5.9 litre biological volume and an overall filter (canister volume of 20 litres!)
4 Eheim 2217's? No! Why?
1. 4 sets of 2 pipes (unsightly).
2. Not efficient in terms of ongoing costs - electricity consumption.
3. They are relatively old filters now, hence the Pro, Pro 2 and now Pro 3 series, they are not easy to maintain (no baskets)
4. The overall pump output would be less. 2217 1000 lph gross (750 lph net under load)
FX5 3500 lph gross (2300 lph net under load)
So you shall have 3000 lph (Eheims) or 4600 lph (Fluvals)
In terms of the impeller being at the bottom of the canister to minimise any potential problems (deoending on your subtrate) ensure the outtake are at least 4" above your substrate level. The Eheim/Fluval debates interest me, and in 30 years fishkeeping I was a total Eheim man from 1992 until this year, until the FX5 came out. The biggest Eheim now, the 2080 DOES have a huge bio-volume BUT after the demise of the 2234 bucket filter in the early 90's, we had the 2260, now the 2080 as the top of the range, the problem being each one had a SMALLER output each time...
I personally used an Eheim 2234 (3500 lph gross) plus a 200 litre sump/wet/dry trickle in a 31" RTC 1250 litre set-up in 1992 and it worked really well.
Personally I would go with either 2 FX5's or a sump tank with a huge pump (such as an AquaMedic Ocean Runner 6500 - 6,500 litres per hour net) that's 1900 lph more than the 2 FX5's combined net output. Hope this is of help to you.