It depends on the flow you want. Each 3/4" drain is capable of flowing about 330gph of gravity fed draining. This means that you can technically flow about 660gph through them, which is a turnover rate of about 3x per hour. However, at that flow you have no safety factor in case one of the drains gets clogged. I like to have at least 2x the draining capability as the flow in the tank. This means that if one drain gets clogged, the other can still handle the flow. With that in mind, you probably shouldn't flow more than 330gph through them, that way you have a safety margin in case of a clog.
For example, I am going to run three H2Overflows, each capable of flowing 1,200gph, on my 220. I am planning to run about 1,500gph of flow through it, but I will be capable of flowing 3,600gph. This way, if one of them becomes clogged I can still handle the full 1,500gph. Now, if two get clogged at the same time, I'm SOL.