Congrats on doing a tank. It's work but you'll enjoy it.
I would NOT use MDF or any other cheaper grade of ply. If you can afford it I would recommend using a true 3/4 plywood. None of the big box stores carry it - some lumberyards still do. Most true 3/4 plys are a high grade anyway. Also true 3/4 measures and cuts how you would expect, which is great for us folks who dont like working with madness like 11/16ths. Besides, your tank is huge at 400 gal. That's 3280 lbs of water. I wouldnt risk it.
In the reply above by A-Kronic there is the thread for my tank. The epoxy I use is the MAX ACR. I'm using it for other aquarium stuff too and I'm really pleased with it. Other folks are using West Sysytem, Pond Armour, etc. Even the guy above has used something called Advantec.
The trick with epoxy (I use) is to get it to "bite" into the wood as a first coat, let it cure, sand it lightly and lay on another coat. You should be good after that.
Keep researching before you start until you feel comfortable. Then, go for it and have fun.