From what I've read about them, they are only effective on smaller tanks. But the big negative is the replacement cost. Many people trash them, or sell them dirt cheap to avoid the high carbon replacement costs. I recall Tom Barr saying on a forum that Co2 injection is the most cost effective long term means of providing Co2 to aquatic plants. If you think about it, it's true. The most expensive part of an injection system is the regulator. If you shop carefully, it's possible to put together a entire Co2 injection system for about the same or even less than the $200 or so charged for that Carbo thing.