Agree with David R.
We are really talking apples and oranges here, but as I have a few tanks that have only refugiums with with water circulating thru plants as filtration I thought I'd weigh in in the "without filtration fish die" comment.
These tanks are lightly stocked, with a ratio of many plants to few fish.
As to fractionation...
The fractionator waste was dried weight in milligrams, because I used 100ml aliquots to extrapolate my results, and mg/L can be significant.
Consider that a reading of only 20mg/L of nitrate is considered stressful to many fish.
I found nematodes, ciliates, and macro invertebrates, of too many species to remember species level ID now, this experiment is a number of years back.
But to me fractionation is as effective as using UV at the free floating micro/macro removal level. It doesn't kill them, but simply removes them from the system altogether.
below is a video of one of my biofractionators working in one of my small ponds, there is a sponge filter in the pond, preceding the biotower. click on the pic to see the video
