All commercial foods contain color enhancing agents, most people just don't understand the basics behind most of the raw ingredients used in fish food, and how they play a role in the color AND the overall health of the fish. Some of the most powerful antioxidant & immune stimulants are also natural color enhancers. Raw ingredients such as antarctic krill, spirulina, and various micro algae such as Haematococcus pluvialis all play a major role in the enhancement of disease resistance & regulation of growth in a fish.
The only way that the shiroji of a koi will be affected negatively by color enhancing agents is if/when they are used in excessive amounts.
When unnatural color enhancement takes place it is typically caused by an excessive use of
synthetic color enhancing agents. When used properly, in controlled quantity,
natural color enhancers will actually make the white portion of a fish, even whiter.
The problem is it is far cheaper for a manufacturer to jack up the color enhancing properties of their feed by simply adding a boat load of synthetic color agents such Carophyll Pink, etc, than by doing things the
natural way. These are the same type of color enhancement agents used by the salmon industry, which is why a farm raised salmon has pink flesh, instead of a bland grey. (guess which ones the consumer would choose to eat?)
It all depends on how much is added to the feed, you just have to pick a number from the slick little color chart & dial in what kind of unnatural color that you are seeking.