I used CopperSafe on my 150G tank about three years ago. The tank had no plants or scaleless fish. It largely had African Cichlids.
I have to say it worked perfectly as it eliminated a parasite I had introduced into the tank when I added a new fish.
I literally saw it heal my favorite fish (Protomelas steveni Taiwan Reef) before my eyes. The parasite must have been embedded in the Taiwan Reef's gills. It had stopped eating about two weeks before the treatment. A few minutes after I dosed with CopperSafe, I saw the Taiwan Reef shake his head violently a few times. Within the hour he was eating (like he hadn't eaten in two weeks).
All the other fish stopped flashing and their activity level picked up after the first day of treatment. I observed no downside to the introduction of copper into the tank.
I have not had a need to use it again, but I would not hesitate.
I have to say it worked perfectly as it eliminated a parasite I had introduced into the tank when I added a new fish.
I literally saw it heal my favorite fish (Protomelas steveni Taiwan Reef) before my eyes. The parasite must have been embedded in the Taiwan Reef's gills. It had stopped eating about two weeks before the treatment. A few minutes after I dosed with CopperSafe, I saw the Taiwan Reef shake his head violently a few times. Within the hour he was eating (like he hadn't eaten in two weeks).
All the other fish stopped flashing and their activity level picked up after the first day of treatment. I observed no downside to the introduction of copper into the tank.
I have not had a need to use it again, but I would not hesitate.