Not if you descend slowly enough...
If you descend or ascend too fast the change in pressure either crushes you like a grape under a military tank or makes you expand like when that vampire in Blade died.
However, if you descend slowly enough (of course the temperature would kill you, but let's ignore the temperature for a while

) then the deeper you go the more gasses that will be dissolved into you, making you denser, allowing you to withstand the pressure. Again, if you ascended slowly enough, those gasses would be taken out of solution slowly enough not to hurt you (gasses leaving solution is what causes the bends).
Sorry, I'm science nerd, I just had to.