I have drilled tanks with and without the center guide but in place. I have also done it with a jig as well. It can be done without a jig, but it is difficult.
You can drill it with water in it, just make sure that you keep debris from falling in the tank or the fish will eat it.
You can drill it with water in it, just make sure that you keep debris from falling in the tank or the fish will eat it.