I have the same 6 ft 125 gal as yours and run three Penguin 350. I have heavy fish load, over a dozen medium to large cichlid, and the water is crystal clear. Very few people use UGF anymore today as canister is essentially external UGF. I maintain a thin substrate, about 1/2 inch gravel, that provides good bio filtration as long as good flow is maintained over it. You better go with more HOBs than Canister for better mechanical filtration as Canister is PIA to clean.