IMO yes. and I'm a long time Marinedand fan. The dual pump arangement allows better flow and prevents bio-wheel stalling. The bio-wheels themselves have much more serface area and the media chambers are largers. That said...I'd avoid any of the B model E400's or E280's. These are the ones with the 'flow control' knobs. they dont work very well...cause excessive noise and tend to make the filters harder to restart. Marineland scrapped the feature by the way and all of the new ones went back to the original style.
The problem with the penguins isn't that they don't work but that they require a lot more maintaince to keep running. That said... I have a penguin 300 in my extras box that ran for 20 years and still does a great job when needed.