Your live rock will be 80% of your filtration, then skimmer, then fuge. I recommend 1.5-2 pounds of live rock per gallon.
I would not recommend wet/dry, they can drive up nitrate and phosphate. Most people found that if they pulled out their bioballs the only difference they saw was a reduction in nitrate concentration.
My tank has no mechanical filtration at all. There is not a single pad, prefilter, or anything. I want to keep all that debris moving until all of my filter feeders get to eat it (sponges, scallops, clams, feather dusters, etc.). There is not reason to trap debris in one spot (which will breakdown into nitrate and phosphate) just to have to add even more food to feed things elsewhere (which will also increase nitrate and phosphate concentrations).
I have a 45 gallon display with a ten gallon sump (all that fits in my stand). I have an AquaC skimmer (runs external to the sump). The sump has three sections. The first handles bubbles (only a couple inches wide), the second is refugium, and the last section is for pumps (about 5"). I also have media reactors hangin off the back of my sump (one for carbon and one for GFO for phosphate).
Natural filtration and water changes is the method I prefer.