I had 3 bichirs and the only one that survived the water change last night was the largest and he had to be evacuated into a cichlid tank temporarily. This is a problem we have had in the past and we cant figure out why. 75 gallon tank, left filter media intact, cleaned out sand (large pleco dead now but was a massive waste contributor.) We took the eels and pleco out because the last time we tried to do a water change something killed half the fish in the tank also. They did great in a little quarantine for the 2 hours with a large air stone. So i took only decorations out and rinsed them only in hot water, we drained the tank to nothing, cleaned the sand and drianed it again until the water was somewhat clean in comparison to the black mass that was there. i know you arent supposed to do all that but the tank had gotten out of hand. Ive done this 5 or 6 times before with other tanks of ours and have never had fish loss in any tanks but this tank and a 20 gallon. I seem to be running into a problem with something that has to do with their gills because all of them start sliming up really bad and then have difficulty breathing. The water is conditioned, treated with bacterial treatment to prevent fish loss. Its petco brand bacterial booster. We have used this in the same way in extreme cases because of circumstances that left us unable to clean the tanks as often. Their slime coats go crazy, eyes glaze over, breathing starts to get difficult, even with their lung the bichirs almost didnt make it. Also API water conditioner. All water levels pristine except hardness. Conditioned tank before replacing fish, bacteria, everything. The 20 gallon we had only killed our catfish. They died without a water change though. We lost 4 striped and 2 spotted raphaels 1 pleco and an irridescent shark. All were in process of quarantine on different water cycles with different filter media almost every time. But we use the 20 for a baby savannah monitor now so what does everyone think about this? I cant stand losing my fish bcause they are like my kids and i need to figure out what this slime cloud gill strangling goo is. I noticed the water seems almost like someone had spit in a cup of water, almost like algae but with absolutely no color. Almost lik a froth in the water and the surface looked clear as day but swampy. Idk how to explain it.